Artifacts

Artifacts are one of the two providers of GDMG, the other being Boss Souls. They grant various buffs that scale into infinity in exchange for the Boss Souls granted upon killing Bosses at the end of every stage, and then Prestiging.

Every 10 Levels past the first will give a large damage boost. So 11, 21, 31, 41....121, 131, 141, etc.